Question 1

Administration of Oral Esomeprazole Tablet both Nexium and Esoz)

Accepted Answer

Patients without swallowing difficulty 1)  Swallow whole with water 2)  Do not chew or crush tablet       Patients WITH swallowing difficulty 1)  Do not chew or crush tablet 2)  Disperse tablet in half a glass of water 3)  Stir until the tablet disintegrates into pellets 4)  Drink the liquid with pellets immediately or within 30 minutes 5)  Rinse the glass with half a glass of water and drink     Patients on Nasogastric Feeding Tube (NGT)   1)  Do not crush tablet 2)  Put the tablet into a syringe and fill syringe with approximately 25mL (up to 50mL) water and approximately 5mL air 3)  Shake the syringe immediately for approximately 2 minutes to disperse the tablet 4)  Hold the syringe with the tip up and check that the tip is not clogged 5)  Attach the syringe to the tube whilst holding it with the tip up 6)  Shake the syringe, then position it with the tip down 7)  Inject 5 - 10 mL into the tube immediately 8)  Invert the syringe after injection (with the tip pointing up) and shake 9)  Turn the syringe with the tip down and inject another 5 - 10mL into the tube immediately 10)  Repeat Steps 7 and 8 until the syringe is empty 11)  Fill the syringe with 25mL (up to 50mL) of water and 5mL of air 12)  Repeat Steps 7 and 8 to wash down any sediment left in the syringe   References1) Esomeprazole Product Inserts (respective brands)                   Last Updated 28th June 2017

Question 2

Preparation of Oral Vitamin K (Phytomenadione)

Accepted Answer

Break the Vitamin K (10mg/mL) ampoule at the neck Using the insulin syringe (29 Gauge, long needle, 3/10 cc), syringe out entire contents from Vitamin K ampoule and deposit it into a clean dry plastic cup Add 9mL of water with a Terumo syringe (no needle). This will give you Vitamin K 10mg in 10mL Using the Terumo syringe, syringe out the required number of mg (1mg = 1mL) as prescribed Deposit this into a second plastic cup and add water to make at least 15mL (to increase total volume for easier consumption) Shake cup slightly to mix well. Give to the patient to drink immediately If alot of oily liquid is left at the bottom after patient drinks, rinse with water and drink again Discard the broken Vitamin K ampoule and insulin syringes responsibly into the sharps bin Last Updated 28th Jun 2017

Question 3

Preparation of Oral Vancomycin solution

Accepted Answer

- For Pharmacy Lab to prepare during office hours   1) Reconstitute and dilute 1 vial of Vancomycin (500mg) using 20mL water for injection (WFI) 2) Diluted solution is now of concentration 25mg/mL 3) Store diluted solution in the refrigerator (2 - 8 degrees Celsius) and use within 24 hours * The stipulated 24 hours time frame is for manually prepared oral solution done by non-lab staff

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Drugs with Special Administration Instructions

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