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Preparation and handling of hazardous drugs for special administration

HAZARDOUS
GUIDE

NOTE: Please consult Drug Information or a pharmacist for specific instructions before proceeding to reconstitute any hazardous drugs, including cytotoxics!

Last updated 04 Jul 2023

Rationale For Closed System Administration of Cytotoxics

  • This closed system is preferred for cytotoxics for which no liquid formulation is available, so as to avoid environmental contamination and exposure of carer to the hazardous medicine. Not recommended to be crushed due to risk of powder inhalation

  • Exposure to such substances is dangerous; therefore, contact with the skin and inhalation of dust should be avoided and protective equipment devices (gloves and mask) must be used

  • Women with pregnancy potential should avoid handling crushed or broken tablets. To wear gloves and mask when handling

  • Suitable protective clothing should be worn. Contaminated equipment should be disposed of as cytotoxic waste

  • Adapted from: White, R., & Bradnam, V. (2015). Handbook of drug administration via enteral feeding tubes. London: Pharmaceutical Press.

References
1) White, R., & Bradnam, V. (2015). Handbook of drug administration via enteral feeding tubes. London: Pharmaceutical Press.
2) Drug Product Inserts for respective drugs

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